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The commonest drug that is certainly used with barbiturates is alcohol, although it will not be uncommon for folks To combine barbiturates with other barbiturates, benzodiazepines, narcotic pain drugs, or nonprescription drugs such as cannabis goods.
pentobarbital increases toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. CYP3A4 inducers may raise the metabolism of ifosfamide to its Energetic alkylating metabolites.
The withdrawal syndrome from drugs like Nembutal can be extremely hazardous as a result of opportunity advancement of harmful signs and symptoms.
pentobarbital decreases levels of amphotericin B deoxycholate by inhibition of GI absorption. Applies only to oral kind of both agents. Minor/Significance Unidentified.
pentobarbital decreases amounts of vandetanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay away from coadministration with powerful CYP3A4 inducers; these drugs cut down exposure to vandetanib by as much as 40%.
pentobarbital will lessen the level or impact of ambrisentan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unknown.
pentobarbital will minimize the level or outcome of nateglinide by impacting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Observe.
pentobarbital will lessen the extent or effect of atazanavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unfamiliar.
pentobarbital will minimize the extent or outcome of irinotecan liposomal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will reduce the level or outcome of rolapitant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Long-time period coadministration of sturdy CYP3A4 here inducers with rolapitant might noticeably lower rolapitant efficacy.
pentobarbital will reduce the extent or effect of itraconazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Mysterious.
pentobarbital will minimize the extent or effect of dexamethasone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will reduce the extent or outcome of fostemsavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.